Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Number of animals low, purity not specified.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Adipic acid was tested as a 40% solution in corn oil. Minimum lethal dose was determined using 1-2 rabbits per group (5010 mg/kg bw one animal, 7940 mg/kg bw two animals). A 24- hour dermal exposure under occlusive conditions was conducted. Necropsy was conducted after a 14-day observation period.
GLP compliance:
no
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Adipic acid
EC Number:
204-673-3
EC Name:
Adipic acid
Cas Number:
124-04-9
Molecular formula:
C6H10O4
IUPAC Name:
adipic acid
Details on test material:
Test substance purity not specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
corn oil
Duration of exposure:
24 hours
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
5010 mg/kg bw one animal, 7940 mg/kg bw two animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
7 940 mL/kg bw

Any other information on results incl. tables

No deaths occurred at 5010 mg/kg bw (0/1) or 7940 mg/kg bw
(0/2). Observations included reduced appetite and activity.
Reduced appetite and activity ( one or two days).

Applicant's summary and conclusion

Executive summary:

No lethality was reported in rabbits following occlusive dermal administration of up to 7940 mg/kg bw of 40 % adipic acid in corn oil for 24 hours. Animals showed reduced appetite and activity and the viscera were normal at necropsy after 14 days observation period (Solutia Inc. 1975).