Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation, purity not specified, only 7 days post observation period, statistics used not specified
Data source
Reference
- Title:
- No information
- Author:
- Horn HJ, Holland EG, Hazleton LW (1957). Safety of adipic acid as compared with citric and tartaric acid. Agricult. Food Chem. 5, 759-762.
Materials and methods
- Principles of method if other than guideline:
- End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "any information on materials and methods including tables".
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- IUCLID4 Test substance: purity not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 3% aqueous solution
- Doses:
- 200, 300, 350 mg/kg bw
- No. of animals per sex per dose:
- 7
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 275 mg/kg bw
Any other information on results incl. tables
RS-Freetext:
Mortality occurred during the first 5 days (200 mg/kg bw =
1/7, 300 mg/kg bw = 4/7, 350 mg/kg bw = 6/7). Animals that
succumbed showed hemorrhagic lungs and irritation of the
intestines. The survivors showed extensive irritation and
adhesions of the visceral organs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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