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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, short documentation, purity not specified, only 7 days post observation period, statistics used not specified

Data source

Reference
Title:
No information
Author:
Horn HJ, Holland EG, Hazleton LW (1957). Safety of adipic acid as compared with citric and tartaric acid. Agricult. Food Chem. 5, 759-762.

Materials and methods

Principles of method if other than guideline:
End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "any information on materials and methods including tables".
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: purity not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 3% aqueous solution
Doses:
200, 300, 350 mg/kg bw
No. of animals per sex per dose:
7

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
275 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
Mortality occurred during the first 5 days (200 mg/kg bw =
1/7, 300 mg/kg bw = 4/7, 350 mg/kg bw = 6/7). Animals that
succumbed showed hemorrhagic lungs and irritation of the
intestines. The survivors showed extensive irritation and
adhesions of the visceral organs.

Applicant's summary and conclusion