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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1925
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data for only one animal published.

Data source

Reference
Title:
No information
Author:
Rose WC, Weber CJ, Corley RC, Jackson RW (1925). The nephropathic action of the dicarboxylic acids and their derivatives. III. Acids of six to nine carbons. J. Pharmacol. 25, 59-64.

Materials and methods

Principles of method if other than guideline:
End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "Remarks on results".
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: purity not specified

TS-Freetext:
neutralized sodium salt

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
4 d
Frequency of treatment:
once a day for 2 consecutive days, third appl. on the 4th day
Doses / concentrations
Remarks:
Doses / Concentrations:
2000 mg/day (1. u. 2. appl.), 4000 mg/day (3. appl.)
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
Post-exposure period: 2 d

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
The authors called adipic acid a mildly nephropathic agent
due to the examined blood parameters (e.g. non-protein
nitrogen, urea-N, creatinine, sugar, NaCl). No statistics
given because data for only one rabbit published.

Applicant's summary and conclusion