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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1925
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data for only one animal published.

Data source

Reference
Title:
No information
Author:
Rose WC, Weber CJ, Corley RC, Jackson RW (1925). The nephropathic action of the dicarboxylic acids and their derivatives. III. Acids of six to nine carbons. J. Pharmacol. 25, 59-64.

Materials and methods

Principles of method if other than guideline:
End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "Remarks on results".
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
IUCLID4 Test substance: purity not specified

TS-Freetext:
neutralized sodium salt

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
4 d
Frequency of treatment:
once a day for 2 consecutive days, third appl. on the 4th day
Doses / concentrations
Remarks:
Doses / Concentrations:
2000 mg/day (1. u. 2. appl.), 4000 mg/day (3. appl.)
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
Post-exposure period: 2 d

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
The authors called adipic acid a mildly nephropathic agent
due to the examined blood parameters (e.g. non-protein
nitrogen, urea-N, creatinine, sugar, NaCl). No statistics
given because data for only one rabbit published.

Applicant's summary and conclusion