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EC number: 204-673-3 | CAS number: 124-04-9
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1925
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data for only one animal published.
Data source
Reference
- Title:
- No information
- Author:
- Rose WC, Weber CJ, Corley RC, Jackson RW (1925). The nephropathic action of the dicarboxylic acids and their derivatives. III. Acids of six to nine carbons. J. Pharmacol. 25, 59-64.
Materials and methods
- Principles of method if other than guideline:
- End point summary transferred from IUCLID 4 data set concluded in OECD/ICCA program during SIAM 18, April 2004, published by UNEP. For further information on materials and methods see field "Remarks on results".
- GLP compliance:
- no
Test material
- Reference substance name:
- Reference substance 001
- Details on test material:
- IUCLID4 Test substance: purity not specified
TS-Freetext:
neutralized sodium salt
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 4 d
- Frequency of treatment:
- once a day for 2 consecutive days, third appl. on the 4th day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/day (1. u. 2. appl.), 4000 mg/day (3. appl.)
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- Post-exposure period: 2 d
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
The authors called adipic acid a mildly nephropathic agent
due to the examined blood parameters (e.g. non-protein
nitrogen, urea-N, creatinine, sugar, NaCl). No statistics
given because data for only one rabbit published.
Applicant's summary and conclusion
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