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EC number: 204-673-3
CAS number: 124-04-9
Under the present test conditions, a single application of 100 mg acipid
per animal into the conjunctival sac of the right eye of three rabbits caused
the following changes:
Corneal opacity was observed in all animals:
- animal no. 1: 1 hour to 72 hours (grade 3), 4 to 6 days (grade 2) and 7 to 15 days (grade 1) after instillation;
- animal no. 2: 1 hour to 72 hours (grade 2) and 4 to 12 days (grade 1) after instillation;
- animal no. 3: 1 hour (grade 3), 24 to 72 hours (grade 2) and 4 to 12 days (grade 1) after instillation.
The fluorescein test performed 24 hours after instillation revealed comeal
staining in animal nos. 1 and 3 (3/4 of the surface) and animal no. 2 (1/2 of
the surface). The fluorescein test performed 7 days after instiltation
revealed corneal staining in animal nos. 1 and 3 (1/2 of the surface) and
animal no. 2 (1/4 of the surface). The fluorescein test performed 14 days
after instillation revealed corneal staining in animal no. 1 (1/4 of the
Irritation of the iris was observed in all animals:
- animal no. 1: 1 hour to 4 days (grade 2) and 5 to 8 days (grade 1)
- animal no. 2: 1 hour and 24 hours (grade 2) and 48 hours to 6 days
(grade 1) after instillation;
- animal no. 3: 1 hour to 72 hours (grade 2) and 4 to 8 days (grade 1)
Conjunctival redness (grade 1) was observed in animal no. one 1 hour to
12 days, in animal nos. two and three 1 hour to 72 hours after instillation.
Conjunctival chemosis (grade 1) was observed in animal nos. one and two 1 hour
to 6 days, in animal no. three 1 hour to 11 days after instillation.
There were no systemic intolerance reactions.
Severe eye irritation was observed in a study performed according to
OECD TG 405, conducted in compliance with GLP after the application of
100 mg adipic acid. Corneal opacity and irritation of the iris was
observed in all animals up to grade 3 and grade 2, respectively. The
observed effects were reversible within 16 days (LPT 2004)
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