Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

WoE: not sensitizing

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The skin sensitizing properties of the structure of Di-(2-ethylhexyl)adipate were considered by expert judgement, and indications for an alert were considered not present. This was confirmed by using a validated quantitative structure-activity relationship (QSAR), OASIS-LMC, that predicted both the parent compound and its metabolites as non-sensitiser. Additionally, the available animal studies, a patch test with rabbits and a Draize test with guinea pigs, did not indicate a skin sensitising effect of DEHA (Mallette 1952; CFTA,1967).

Justification for classification or non-classification

Based on the available data, DEHA is considered to be not sensitising. In accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for sensitisation.