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Registration Dossier
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EC number: 203-090-1 | CAS number: 103-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Partitioning of substances into the different environmental compartments depends mainly on their physico-chemical properties. Since the water solubility of Bis(2-ethylhexyl) adipate (DEHA) is very low (0.0032 mg/L) and the log Pow value high (8.94), the substance is expected to mainly distribute to sediment and soil. However, as DEHA and the relevant metabolite 2-ethylhexanoic acid are readily biodegradable according to the OECD criteria, DEHA and its degradation products will not be persistent in the environment.
DEHA is not expected to evaporate into the atmosphere due to the low vapor pressure of < 0.0001 Pa at 20 °C. The more volatile transient metabolites (2-ethylhexanol, 2-ethylhexanal) are assumed to be rapidly oxidized to the respective acid (2-ethylhexanoic acid), which is not considered to be volatile. If entering the atmosphere, DEHA and its metabolites will be rapidly degraded by photochemical processes. Thus, long-range transport through the atmospheric compartment is not expected. This is confirmed by results from the Swedish National Screening Programme 2004 (Remberger et al. 2005). Abiotic hydrolysis is not relevant, since the substance is readily biodegradable and thus expected to be eliminated through biodegradation in natural waters. Additionally, an estimated rate of hydrolysis is low.
Based on the rapid environmental biodegradation and metabolisation via enzymatic hydrolysis, relevant uptake and bioaccumulation in aquatic organisms is not expected. Enzymatic breakdown will initially lead to the free dicarboxylic acid and the free alcohol. From literature it is well known, that these hydrolysis products will be metabolised and excreted in fish effectively (for detailed information please see chapter 5.3 of technical dossiers). This is supported by low BCF values calculated for DEHA and its transient metabolites (BCF << 2000 L/kg ww; BCFBAF v3.01; Arnot-Gobas, including biotransformation, upper trophic).
Remberger et al. 2005. Results from the Swedish National Screening Programme 2004, Subreport 1: Adipates. IVL Report B1645, IVL Swedish Environmental Research Institute
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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