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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
German Chemical Society Advisory Committee on Existing Chemicals of Environmental Relevance. Di-(2-ethylhexyl)adipate.
Author:
BUA
Year:
1996
Bibliographic source:
BUA Report 196. S. Hirzel Wissenshaftliche Verlagsgesellschaft, Stuttgart, 1996.
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) adipate
EC Number:
203-090-1
EC Name:
Bis(2-ethylhexyl) adipate
Cas Number:
103-23-1
Molecular formula:
C22H42O4
IUPAC Name:
bis(2-ethylhexyl) adipate
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
Volume of 0.1 ml was instilled into one eye of 6 albino rabbits . The other eye remained untreated .
Observation period (in vivo):
The eyes were examined at 24, 48, and 72 hours after treatment.
Number of animals or in vitro replicates:
6 albino rabbits

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: no data
Time point:
other: 24, 48, and 72 hours
Remarks on result:
other: no irritation was observed at any timepoint.
Other effects:
no data

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information

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