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EC number: 231-441-9 | CAS number: 7550-45-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Titanium tetrachloride is corrosive to the skin, the eyes and irritating to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was performed in 1949 and did not follow any recognisable guideline. Application to the skin was carried twice per day on three consecutive days. Nevertheless, the conclusion of the study is consistent with expectation for the test substance, which hydrolysis to produce hydrochloric acid in contact with moist air and surfaces, and is therefore considered reliable.
- Principles of method if other than guideline:
- Undiluted test substance was applied to an area of clipped skin on each of three white guinea pigs. Applications were made twice per day on three
consecutive days. - GLP compliance:
- no
- Species:
- guinea pig
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No information available.
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- No information available.
- Duration of treatment / exposure:
- No information available.
- Observation period:
- No information available.
- Number of animals:
- 3
- Details on study design:
- No information available.
- Irritation parameter:
- other:
- Remarks:
- No data available
- Basis:
- other:
- Remarks:
- No data available
- Time point:
- other: No data available
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- The result of exposure was a skin burn in each case which resulted in the destruction of the outer layers of the skin comparable to a second degree heat burn.
- Irritant / corrosive response data:
- The result of exposure was a skin burn in each case which resulted in the destruction of the outer layers of the skin comparable to a second degree heat burn.
- Other effects:
- The authors of the study report that in addition to liberation of HCl, the reaction of titanium tetrachloride with water is strongly exothermic and may therefore cause heat burns in addition to chemical corrosivity.
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Application of undiluted TiCl4 to the skin of guinea pigs resulted in tissue destruction comparable to second degree thermal burns. TiCl4 hydrolyses rapidly in contact with moisture, liberating hydrochloric acid, therefore the result of the study is consistent with expectation for exposure to HCl, and it can be concluded that TiCl4 is corrosive to skin.
Reference
No information was provided in the test report relating to scores for irritation parameters. The result of exposure was a skin burn in each case which resulted in the destruction of the outer layers of the skin comparable to a second degree heat burn.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- other justification
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
- Conclusions:
- The eye irritation study does not need to be conducted as the substance is corrosive.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
A study in guinea pigs showed second degree burns. Hydrolysis of titanium tetrachloride produces hydrochloric acid, which is labelled as C; R34 under Directive 67/548/EEC and ‘Skin corr. 1B Causes severe skin burns and eye damage’ under 1272/2008. Titanium tetrachloride itself is labelled as C; R34 under Directive 67/548/EEC and ‘Skin corr. 1B Causes severe skin burns and eye damage’ under 1272/2008.
In accordance with Column 2 of REACH Annex VII, Eye irritation studies do not have to be carried out because the available information indicates that the substance meets the criteria for classification as corrosive to skin. Based on the above stated results on skin corrosion titanium tetrachloride is deemed similarily corrosive to the eye Category 1 (Danger, H318: Causes serious eye damage) according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).
In a respiratory irritation study (see chapter 7.9.3: Specific investigations: respiratory irritation 7.9.3.002 DuPont 1980) an RD50 value of 2.43 mg/L was determined for the rat following the method of Alarie. Based on its irritating action on the respiratory tract, titanium tetrachloride is classified as acute inhalation toxicity category 2 (H330: Fatal if inhaled.) and as STOT SE Category 3 (H335: May cause respiratory irritation.).
Justification for classification or non-classification
Hydrolysis of titanium tetrachloride produces hydrochloric acid, which is sufficient to justify the classification of titanium tetrachloride. This conclusion is confirmed by test results and by accidental human exposure.
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