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EC number: 231-441-9 | CAS number: 7550-45-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
A review of aquatic ecotoxicity data sources for titanium tetrachloride (CAS 7550-45-0) located only a single result for the substance. A 9-hour IC50 (inhibitory concentration) of 20 mg/L has been determined by Sauvant et al (1995) for effects on population growth of a ciliate protozoan (Tetrahymena pyriformis). In the setting of this test the effects of titanium tetrachloride are clearly related to the pH effect caused by the hydrogen chloride (CAS 7647-01-0) released in a fourfold molar amount during the rapid hydrolysis. The other transformation product, titanium dioxide (CAS 13463-67-7), is considered inert and non-poisonous in the relevant isomolar levels. The hydrogen chloride will dissociate fully in hydronium ions (CAS 12586-59-3) and chlorides (CAS16887-00-6), of which the latter is not a harmful substance. Thus observed effects in organisms exposed in unbuffered aqueous media may be due to pH. In water with no buffering capacity the addition of a concentration of 0.47 mg/L of titanium tetrachloride would be sufficient to lower the pH (increase the acidity) from a value of 7.0 to a value of 5.0. The concentration required to achieve this change would rise to approximately 5.2 mg/L in poorly buffered water (10 mg/L as CaCO3). In moderately buffered water (250 mg/L as CaCO3) a shift from pH 7.0 to pH 5.0, that might be biologically intolerable, would only occur when the added concentration of titanium tetrachloride exceeded ca. 119 mg/L, which is above the regulatory cut-off limit for acute aquatic toxicity. Acidity effects are not true toxic effects and accordingly considered not relevant for assessment
The titanium dioxide and pH effect levels diverge by more than three orders of magnitude with regard to aquatic micro-organisms (Daniels 2008 and Egeler & Goth 2009). It seems unlikely that tolerable pH drops could have any influence on the biological activity of titanium dioxide.
In consequence the effects of the transformation products of titanium tetrachloride were assessed by read across from titanium dioxide as well with regard to micro-organisms.
The assessment of the titanium dioxide effects revealed no indication of any hazard to the aquatic life of the analogue material titanium tetrachloride. As no effect levels were reached no threshold concentrations were derived and no starting points for the calculation of aquatic PNECs is given.
In conclusion titanium tetrachloride and its hydrolysis products do not pose a risk to the aquatic life.
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