Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-441-9 | CAS number: 7550-45-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Risk characterisation must, for all end points, address primarily the hydrolysis products.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 0.1 min
- at the temperature of:
- 4 °C
Additional information
- Rigo M, Canu P, Angelin L, Della Valle G (1998) Kinetics of TiCl4 Hydrolysis in a Moist Atmosphere, Industrial & Engineering Chemistry Research 37(4):1189-95
- Watson PD, Kibler AL (1931) The Relation between Obscuring Power and Particle, Number and Size of Screening Smoke. DOI: 10.1021/j150322a013 J. Phys. Chem. 35(4):1074–90
The hydrolysis study does not need to be conducted as substance produces insoluble oxide after rapid hydrolysis. Waterborne titanium tetrachloride hydrolyses rapidly with an assumed half-life of below 0.1 min (Fisk et al 2010). Therefore measurement of the hydrolysis rate is not technically feasible. The hazard assessment bases accordingly on the hydrolysis products.
Titanium tetrachloride hydrolyses to in two steps to hydrogen chloride (CAS 7647-01-0) and titanium oxychloride (CAS 92344-13-3), which hydrolyzes to titanium dioxide (CAS 13463-67-7) and again hydrogen chloride. Intermediate formation of hydroxides, e.g. titanium dihydroxide oxide (CAS 12026-28-7) and/or titanium hydroxide (CAS 12651-23-9 or 20338-08-3) is probable. The titanium dioxide formed is amorphous or has weak crystallinity but corresponds finally to the naturally occurring mineral rutile albeit in micro-disperse form. It is considered stable under environmental conditions (Fisk et al 2010, Kim et al 1999).
According to the OECD SIDS report on hydrogen chloride (SIAR 2002) hydrogen chloride gets readily dissociated in contact with water into chlorides (CAS 16887-00-6) and via the proton (CAS 12586-59-3) into hydronium ions (CAS 13968-08-6).
Rigo et al (1998) investigated the kinetics of titanium tetrachloride in a moist atmosphere using tailor made laboratory reactors. In the presence of any air humidity rapid hydrolysis forms the volatile compound Ti(OH)2Cl2 instantaneous together with 2 mol hydrogen chloride. The former forms a very fine dust, which easily evolves to aerosols and hydrolyses further to titanium hydroxide (Rigo et al 1998, Watson & Kibler 1931). The half life of the second reaction step is ca. 6 h (Rigo et al 1998). Eventually the above mentioned amorphous complexes and finally the titanium dioxide particle sizes ranges about 400 to 700 nm (Watson & Kibler 1931).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
