Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology updates. Dimethylsulfoxide
- Author:
- Willhite CC, Katz PI
- Year:
- 1 984
- Bibliographic source:
- J. Appl. Toxicol., 4(3), 155-60
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- skin irritation / corrosion
- eye irritation
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Results and discussion
- Results:
- In humans, topical and intradermal application of DMSO produced garlic breath, mast cell degranulation, an increase in polymorphonuclear leukocytes and perivascular eosinophils, itching, and histamine mediated and non-histamine dependent whealing and erythematous flare.
Two drops of >50% DMSO in the eye caused a temporary burning sensation and vasodilatation; concentrations of 50% exhibited no effects.
Applicant's summary and conclusion
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