Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication not available
Data source
Reference
- Reference Type:
- publication
- Title:
- A biological implication of DMSO based on a review of its chemical properties
- Author:
- Rammler DH and Zaffaroni
- Year:
- 1 967
- Bibliographic source:
- Ann NY Acad. Sci. 141, 13-23
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Results and discussion
- Results:
- In man, DMSO is oxidized into dimethylsulfone DMSO2, metabolite excreted by urine (17-22 %).
DMSO is reduced into dimethylsulfide, DMS, a volatile metabolite, responsible for garlic odour of exhaled air (1 %).
About 85 % is excreted unchanged, both by urine (50 %) and feces (50 %).
The half time for elimination in volunteers given 1000 mg/kg intravenously is 4 days.
By oral route, the same dose is excreted about 51 % as DMSO and about 10 % DMSO2 in urine within 120 hrs.
Applicant's summary and conclusion
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