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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Toxicology updates. Dimethylsulfoxide
Author:
Willhite CC, Katz PI
Year:
1984
Bibliographic source:
J. Appl. Toxicol., 4(3), 155-60

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
skin irritation / corrosion
eye irritation
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl sulfoxide
EC Number:
200-664-3
EC Name:
Dimethyl sulfoxide
Cas Number:
67-68-5
Molecular formula:
C2H6OS
IUPAC Name:
dimethyl sulfoxide

Results and discussion

Results:
In humans, topical and intradermal application of DMSO produced garlic breath, mast cell degranulation, an increase in polymorphonuclear leukocytes and perivascular eosinophils, itching, and histamine mediated and non-histamine dependent whealing and erythematous flare.
Two drops of >50% DMSO in the eye caused a temporary burning sensation and vasodilatation; concentrations of 50% exhibited no effects.

Applicant's summary and conclusion