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EC number: 200-664-3 | CAS number: 67-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
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- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Plasma Concentrations and Pharmacokinetics of Dimethylsulfoxide and Its Metabolites in Patients Undergoing Peripheral-Blond Stem-Cell Transplants
- Author:
- Egorin MJ, Rosen M, Sridhara R, Sensenbrenner L and Cottler-Fox M
- Year:
- 1 998
- Bibliographic source:
- J Clin Oncol, 16(2), 610-615
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
- Details on test material:
- Test compound Dimethylsulfoxyde
CAS no.: 67-68-5
Source: Research Industris, Salt Lake City, Utah
Batch : no data
Purity : no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Infusions lasted between 20 and 120 minutes.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
18 to 58.5 ml (equivalent to 254 to 824 mmol) DMSO
- No. of animals per sex per dose / concentration:
- Ten patients who underwent autologous stem-cell transplant preserved with DMSO for a variety of solid tumors or lymphoma (5 carcinomas of the breast. one ovarian carcinoma, one testicular carcinoma, and three non-Hodgkin's lymphotnas) participated in this study.
- Details on dosing and sampling:
- Blood was sampled at multiple times after the stem-cell infusion. Urine was pooled during the 24 hours post-infusion. DMSO, DMSO2, and DMS were assayed simultaneously by gas chromatography. A one-compartment model with saturable elimination proved most suitable for fitting plasma DMSO concentration versus time data.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- DMSO2 was detectable in plasma by 5 minutes after the end of infusion (Figure 2) and its concentrations increased in plasma during the first 24 hours after completion of DMSO delivery. Peak plasma DMSO concentrations were 19.1 ± 6.3mmol/L. Between 24 and 48 hours (the last time at which blood was sampled), plasma concentrations of DMSO2 mained stable at 4.5 to 5 mmol/L. DMS was readily detectable in plasma by 5 minutes after completion of DMSO delivery (Figure 2), and plasma concentrations of this DMSO metabolite remained essentially constant at 3 to 5 mmol/L troughout the 48 hours during which blood was sampled.
- Details on excretion:
- Urinary excretion of DMSO and DMSO2 accounted for 44% ± 4% and 4% ± 1%, respectively, of the administered DMSO dose. Renal clearance of DMSO was 14.1± 3.4 ml/min
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- other: Vc (DMSO) = 37.3 +/- 17.0 L
- Toxicokinetic parameters:
- other: Vmax (DMSO) = 0.99=/- 0.57 mmol/h
- Toxicokinetic parameters:
- other: Km (DMSO) = 5.2 +/- 5.0 mmol/L
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Dimethyl sulfone (DMSO2) and dimethyl sulfide (DMS)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
In human patients undergoing an autologous stem-cell transplant preserved with DMSO, plasma concentrations of DMSO and its metabolites (DMS and DMSO2) remained essentially constant at 3 to 5 mmol/L troughout the 48 hours during which blood was sampled.
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