Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

Key value for chemical safety assessment

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
2 800 mg/m³

Additional information

In a repeated inhalation toxicity study (Kenny, 2000) performed following the OECD and US EPA OPPTS Guidelines and in compliance with GLP, 4 groups of rats (10 males and 10 females) of the Crl:CD®BR strain were exposed to analysed chamber concentrations of 0, 0.310, 0.964 and 2.793 mg DMSO/l, 6 hours a day, 7 days a week for 13 weeks using a snout only exposure system. An additional 10 male and 10 female rats concurrently exposed at the Control and High dose levels were restrained following the final exposure for the further 4 weeks of withdrawal (recovery) to assess the reversibility of any adverse findings. A functional observation battery was conducted in all groups. Comprehensive observations were conducted prior to the start of exposure, during week 12 and during the recovery period. A shortened battery of observations was conducted during each of weeks 1-11 of the study. No behavioural changes that were considered indicative of neurotoxicity were observed.

Justification for classification or non-classification

Based on the available data, no classification for repeated toxicity has to be applied for DMSO according to EU Directive 67/584/EEC and EU regulation (EC) No 1272/2008 (CLP).