Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- The effect of dimethyl sulfoxide and sub-zero temperatures on loach
- Author:
- VEPRINTSEV, B.N. et al
- Year:
- 1 989
- Bibliographic source:
- Embryos.Kriobiologiya, 2, 16-21 (Russ) (abstract)
Materials and methods
- Type of medium:
- aquatic
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Results and discussion
Any other information on results incl. tables
The toxic
and cryoprotective effects of 10% DMSO concentration were studied in
early stages of loach embryo development (stage 2(8 blastomeres) to
stages 27-33 (organogenesis)). Embryos at stages 22-28 of development
were most resistant to the toxic effects of DMSO.
Maximum cryoprotection was observed at stages 25-33.The number of
embryos which did not survive increased with decreasing temperature from
0 to -10 degree C.The number of embryos with developmental defects was
greatest at -2 degree C.At lower temperatures, embryos died rather than
developed abnormally.
Applicant's summary and conclusion
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