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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
fish early-life stage toxicity
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2022
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
SOFTWARE
QSAR ECOSAR V 1.1

Data source

Reference
Reference Type:
other: QSAR
Title:
The ECOSAR (ECOlogocal Structure Activity Relationship) Class Program for Microsoft Word
Author:
Arkema
Year:
2022
Bibliographic source:
U.S. Envionmental Protection agency, Office of Chemical Safety and Pollution Prevention, July 24, 2012

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The ECOSAR model from US EPA Episuite software: ECOSAR v1.1
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl sulfoxide
EC Number:
200-664-3
EC Name:
Dimethyl sulfoxide
Cas Number:
67-68-5
Molecular formula:
C2H6OS
IUPAC Name:
dimethyl sulfoxide
Test material form:
liquid
Details on test material:
Chemical registery number : CAS 67-68-5 / EC 200-664-3
Chemical name : dimethyl sulfoxide (DMSO)

Results and discussion

Effect concentrations
Dose descriptor:
EC50
Effect conc.:
3 459.78 mg/L
Remarks on result:
ChV (chronic value, QSAR)
Details on results:
Calculated value

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated ChV value from ECOSAR v1.11 is 3459.780 mg/L.
Executive summary:

A simulation was performed using ECOSAR v1.11. The calculated value supports the non toxicity of the dimethylsulfoxide