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Ecotoxicological information

Biotransformation and kinetics

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Administrative data

Endpoint:
biotransformation and kinetics
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
The effect of dimethyl sulfoxide and sub-zero temperatures on loach
Author:
VEPRINTSEV, B.N. et al
Year:
1989
Bibliographic source:
Embryos.Kriobiologiya, 2, 16-21 (Russ) (abstract)

Materials and methods

Type of medium:
aquatic

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl sulfoxide
EC Number:
200-664-3
EC Name:
Dimethyl sulfoxide
Cas Number:
67-68-5
Molecular formula:
C2H6OS
IUPAC Name:
dimethyl sulfoxide

Results and discussion

Any other information on results incl. tables

The toxic and cryoprotective effects of 10% DMSO concentration were studied in early stages of loach embryo development (stage 2(8 blastomeres) to stages 27-33 (organogenesis)). Embryos at stages 22-28 of development were most resistant to the toxic effects of DMSO.
Maximum cryoprotection was observed at stages 25-33.The number of embryos which did not survive increased with decreasing temperature from 0 to -10 degree C.The number of embryos with developmental defects was greatest at -2 degree C.At lower temperatures, embryos died rather than developed abnormally.

Applicant's summary and conclusion

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