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EC number: 200-664-3 | CAS number: 67-68-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicologic study of dimethyl sulfoxide
- Author:
- Willson JE, Brown DE and Timmens EK
- Year:
- 1 965
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 7: 104-112
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Each dose was administered over a 1-minute interval
- Doses:
- 2.5, 5.0, and 10 g/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Median lethal dose (LD50), 95% confidence limit, probit slopes and maximum tolerated dose (LD0.1) were determined.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 750 mg/kg bw
- Mortality:
- With one exception, deaths occurred within the first 24 hours
- Clinical signs:
- Death was preceded by tremors, myasthenia, dyspnea, and occassionally, convulsions
Non-lethal doses of DMSO produced decreased motor activity and myasthenia
Any other information on results incl. tables
The LD0.1 was calculated to be 2.74 g/kg.
Applicant's summary and conclusion
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