Diphenyl ether

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

LD50 study in female rats, 5 rats/dose level.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diphenyl ether

EC Number:

202-981-2

EC Name:

Diphenyl ether

Cas Number:

101-84-8

Molecular formula:

C12H10O

IUPAC Name:

phenoxybenzene

Details on test material:

Industrial Grade Diphenyl Oxide
Reference No.: XA-1075-L
Appearance: light yellow liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

female

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

single-dose intubation using calibrated syringe and suitable rubber catheter

Doses:

1.58, 2.0, 2.52, 3.16 or 3.98 g/kg

No. of animals per sex per dose:

5 female rats/dose

Control animals:

no

Details on study design:

Animals subjected to acute oral toxicity studies were fed by single-dose intubation using a calibrated syringe and a suitable rubber catheter. Animals were fasted overnight prior to dosing. Material was administered undiluted. All animals were weighed and observed at intervals over a two-week post-feeding period or until any weight loss is regained and the animals appear healthy. Pathological observation is made on representative animals.

Statistics:

No data

Results and discussion

Preliminary study:

Not applicable

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

2.83 other: g/kg

95% CL:

2.49 - 3.21

Mortality:

Mortality: 0/5 for 1.58 g/kg, 0/5 for 2.0 g/kg, 1/5 for 2.52 g/kg, 4/5 for 3.16 g/kg and 5/5 for 3.98 g/kg

Clinical signs:

other: 1st day- Starting at 2.52 g/kg and up, the rats looked sleepy and depressed; 3rd day- rats given 2.52 g/kg had urine soaked hind quarters and rats given 3.16 g/kg were urine soaked and had red nasal discharge

Gross pathology:

No data

Other findings:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: United Nations GHS

Conclusions:

The acute oral lethality of the test material is low. The acute oral LD50 in female rats was calculated to be 2830 mg/kg body weight (95% confidence limits 2490-3210 mg/kg).

Executive summary:

A sample of industrial grade diphenyl oxide XA-1075-L, was submitted to Chemical Biology Research for evaluation of acute oral lethality, eye and skin irritation properties, and for definition of industrial handling hazards involving acute exposures. The test material is in the early stages of application development. The objective of this study was to provide initial toxicological information on the industrial grade material. As applications are developed, additional appropriate toxicological tests may be required.

The acute oral lethality of the test material is low. The acute oral LD50 in .female rats was calculated to be 2.83 g/kg body weight (95% Confidence Limits 2.49-3.21 g/kg).* There is little likelihood that internal. injury would result from acute ingestion of amounts of the material one might encounter incidental to industrial handling.

Eye contact with the test material would likely result in very slight pain, very slight transient conjunctival inflammation, and possibly a slight transient corneal injury. Safety glasses are recommended whenever the likelihood of eye contact exists.

Prolonged skin contact with the test material would likely result in slight redness and moderate swelling. However, if contact is repeated and/or contaminated clothing is worn for several days moderate redness, moderate swelling and a moderate chemical burn may result. The test material is not likely to be absorbed

through the skin in acutely toxic amounts. Prolonged and/or repeated skin contact should be avoided. If contact occurs, the skin should be decontaminated with soap and water and contaminated clothing thoroughly cleaned before re-use.