Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Two short-term toxicity studies with Diphenyl Oxide (DPO or Dipheny Ether) were conducted with Daphnia magna following available guidelines at different laboratories. A quantitative structure-activity relationship (QSAR) model was used to estimate the acute toxicity.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1.96 mg/L

Additional information

One key study was identified that provided acute toxicity test results with Daphnia magna exposed to Diphenyl Oxide (DPO or Diphenyl Ether). This study was rated a Klimisch score of 1 and was considered reliable reporting a 48-hr EC50 value of 1.96 mg/L (95% confidence interval of 1.74 - 2.21 mg/L).

A supporting study was rated a Klimisch score of 1 and was considered reliable reporting a 48-hr LC50 value of 1.7 mg/L.

These results were corroborated by a quantitative structure-activity relationship (QSAR) model (ECOSAR v1.11 by U.S. Environmental Protection Agency, 2012) estimation which shows the 48-hr LC50 of 1.0 mg/L.