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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Description of key information

Acute toxicity test results were available for two freshwater fish species, the rainbow  trout (Oncorynchus mykiss) and the fathead minnow (Pimephales promelas) exposed to Diphenyl Oxide (DPO or Diphenyl Ether).  

Key value for chemical safety assessment

LC50 for freshwater fish:
4.2 mg/L

Additional information

One key study (Klimisch score of 2) was identified with a freshwater species, the rainbow trout (Oncorynchus mykiss). This key study reported a 96-hr LC50 values of 4.2 mg/L. Two supporting studies were also identified that provided 96-hr LC50 values for the fathead minnow (Pimephales promelas) of 5.5 mg/L and 13 mg/L. All three studies followed available guidelines but were nonGLP.