Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data on a non-GLP study. However data are consistent with low toxicity observed via oral route and low degree of dermal penetration.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: No data
Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
3160, 5010 or 7940 mg/kg
No. of animals per sex per dose:
1-2/sex/dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Mortality:
No animals died
Clinical signs:
Signs of Intoxication: Reduced appetite and activity (3 -5 days)
Gross pathology:

Survivors (14 days): Viscera appeared normal

Any other information on results incl. tables

Mortality: 0/1 male at 3160 mg/kg, 0/1 female at 5010 mg/kg and 0/1 male and 0/1 female at 7940 mg/kg

Signs of Intoxication: Reduced appetite and activity (3 -5 days)

Survivors (14 days): Viscera appeared normal

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: United Nations GHS
Conclusions:
The acute dermal toxicity in rabbits is >7940 mg/kg.
Executive summary:

Undiluted Diphenyl Oxide was dermally applied to Sprague-Dawley albino rats at dose levels of 3160, 5010 or 7940 mg/kg. The acute dermal toxicity in rabbits was determined to be >7940 mg/kg.