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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Acute toxicity test results were available for two freshwater fish species, the rainbow  trout (Oncorynchus mykiss) and the fathead minnow (Pimephales promelas) exposed to Diphenyl Oxide (DPO or Diphenyl Ether).  

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
4.2 mg/L

Additional information

One key study (Klimisch score of 2) was identified with a freshwater species, the rainbow trout (Oncorynchus mykiss). This key study reported a 96-hr LC50 values of 4.2 mg/L. Two supporting studies were also identified that provided 96-hr LC50 values for the fathead minnow (Pimephales promelas) of 5.5 mg/L and 13 mg/L. All three studies followed available guidelines but were nonGLP.