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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Three short term toxicity tests to freshwater fishes were available. One study was identified as the key study and reported a 96-hr LC50 value for rainbow trout (Oncorynchus mykiss) of 4.2 mg/L Diphenyl Oxide (DPO or Diphenyl Ether). Two laboratory studies and a quantitative structure-activity relationship (QSAR) model estimation were available for short term toxicity to aquatic invertebrate Daphina magna. A key study reported 48 -hr EC50 value of 1.96 mg/L DPO. Two laboratory studies and a QSAR model estimation were available for short term toxicity to aquatic plant green algae

Psuedokirchnerilla subcapitata (formerly known as Selenastrum capricornutum). A key study reported 72 - hr ErC50 (growth rate) of 0.58 mg/L and EbC50 (biomass) of 0.405 mg/L using initial measured concentration. The results were recalculated using arithmetic mean measured concentration between initial and 72 hour measurement and the values were 72 - hr ErC50 (growth rate) of 0.455 mg/L and EbC50 (biomass) of 0.304 mg/L.

An additional study examined the possible genotoxic and teratogenic effects of DPO on two species of sea urchings (Paracentrotus lividus and Sphearechinus granularis). Also, the potential effect of diphenyl ether on activated sludge microorganisms maintained in an aerobic environment resulted in an EC50 of >100 mg/l (highest concentration tested).