Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
discriminating dose
3 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

Experimental studies in rats show a very low acute oral toxicity for 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters. No clinical effects were observed at doses of 3000 mg/kg. Mortalities occurred at doses of 17319 mg/kg and above.

Two acute dermal toxicity studies of 1,2,4 -Benzenetricarboxylic acid, mixed decyl and octyl triesters show also a low dermal toxicity. No mortalities nor clinical effects were observed at the limit dose of 2000 mg/kg.

Based on the available data it can be concluded that 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters is of very low acute oral and dermal toxicity.

Justification for classification or non-classification

Th oral and acute LD50 -values exceed clearly the cut-off value for classification according to Regulation (EC) No 1272/2008.

Overall, the acute oral and dermal toxicity of 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters is low and does not warrant classification.