Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In the key study according to OECD 406 to assess the sensitising properties of 1,2,4 -benzenetricarboxylic acid, decyl octyl ester a maximisation test in guinea pigs has been conducted with test concentrations of 10% (induction) and 100% (challenge). No evidence of skin sensitisation was observed in any of the treated animals.

In a supporting study a LLNA-test according to OECD 429 was conducted with the test item.

1,2,4 -benzenetricarboxylic acid, decyl octyl ester was considered to be a non-sensitizer under the conditions of the test.

Justification for classification or non-classification

The results of the sensitisation tests show that1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triestersdoes not need to be classified according to

EU regulations (Directive 67/548/EEC and Regulation (EC) No 1272/2008.

There are data lacking for the classification of 1,2,4 -Benzenetricarboxylic acid, decyl octal ester with regard to respiratory

sensitisation.