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EC number: 290-754-9 | CAS number: 90218-76-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Acute skin and eye irritation studies with 1,2,4 -Benzenetricarboxylic acid, decyl octyl ester have been conducted in rabbits.
In the key study 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters was slightly irritating to the skin,
the effects in the skin were fully reversible within 8 days. In a supporting study no skin irritation was found.
In the key study to test the acute irritant effect of 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters on the eyes and mucosa, 0.1 cm³ of the liquid test substance was administered into the conjunctival sac of one eye of each of three male rabbits. After exposure for 72 hours, the eyes were washed out with warm physiological saline. The test was carried out according to OECD guideline 405 (12 May 1982).
The test showed that administration of 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters caused no irritation reactions at cornea and iris. At the conjunctivae 1 hour after application circumcorneal injections in all animals and mild discharge in one animal were observed, after 24 hours all animals were free of symptoms.
The following mean values, based on the results from the 24 -, 48 - and 72 hour-readings were calculated:
Cornea opacity: 0.0
Iris lesion: 0.0
Redness of conjuntiva: 0.0
Oedema of conjunctiva: 0.0
Based on the result of this study 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters was judged to be non irritating to eyes and mucosa.
In a supporting study the test item produced a maximum group mean score of 6.7 (at 1 hour observation) was slightly irritant.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
The results of the skin and eye irritating studies show that 1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters does not warrant classification according to Regulation (EC) No 1272/2008.
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