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Diss Factsheets

Administrative data

basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

The materiial is likely to be absorbed after ingestion. Metabolism and excretion will include de-esterification and elimination via the urine.
Executive summary:

The substance is a trimellitate ester with linear C8 and C10 alkyl chains. Experimental data are not available for the assessment of the toxicokinetic properties of the C8 -C10 trimellitate and read-across for toxicokinetic property assessment is therefore a possible approach to characterise toxicokinetic endpoints for the substance. Based on structurally similarity to phthalate esters (with two instead of three carboxylic functions) a similar toxicokinetic behaviour can be expected.

Various reviews of different phthalate esters by the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS) are available. The data on the toxicokinetics indicate that phthalates in general are likely to be rapidly absorbed as the monoester from the gut and excreted via the urine.