Registration Dossier
Registration Dossier
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EC number: 203-677-2 | CAS number: 109-52-4
Endpoint summary
Administrative data
Description of key information
Additional information
Three fish studies were available for Valeric Acid. Two studies were non-GLP with fish exposed to pure Valeric Acid, while the third GLP study exposed Rainbow Trout to a commercial mixture of ca. 64% Valeric Acid and 36% 2 -methylburtyric acid. Reportable endpoints included a 96 -hr LC50 value of 39 mg/L with Pimephales promelas exposed to pure Valeric Acid and a higher value of 75.9 mg/L for Rainbow Trout exposed to the mixture. In a preliminary study with the mixture in which the pH of the test solutions were adjusted to approximately that of control water, no fish mortality occurred up through the highest concentration of 1000 mg/L. A short-term NOEC of 500 mg/L was reported for the golden orfe.
Two studies are available to assess the acute toxicity of Valeric Acid to the cladoceran, Daphnia magna. A GLP-guideline study conducted with a commercial mixture of valeric acid (ca. 64%) and 2 -methylbutyric acid (ca. 36%) has been selected as the key study as this study is reliable without restrictions (Klimisch 1). The EC50 (48 hours) reported in this study is 88.1 mg/l and was determined from test solutions with no pH adjustment. A preliminary study with the mixture showed that toxicity was reduced with no mortality of test organisms occurring through 100 mg/L with pH adjustment of the test solutions. This endpoint is supported by a non-GLP study conducted with pure valeric acid. The EC50 (48 hours) reported in this supporting study is 45 mg/l.
Two studies are available to assess the acute toxicity of valeric acid to algae. A GLP-guideline study conducted with pure valeric acid
has been selected as the key study as this study is reliable without restrictions (Klimisch 1). The ErC50 (72 hours) reported in this study is 29.3 mg/l. This endpoint is supported by a GLP-study conducted with a commercial mixture of valeric acid (ca. 64%) and 2 -methylbutyric acid (ca. 36%). The ErC50 (48 hours) reported in this supporting study is 73.2 mg/l.
A toxicity to microorganisms study with limited documentation reported that no toxicity was observed at 1500 mg/L Valeric Acid.
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