Registration Dossier
Registration Dossier
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EC number: 203-677-2 | CAS number: 109-52-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Test to assess acute toxicity in mice after intraperitoneal substance application
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Valeric acid
- EC Number:
- 203-677-2
- EC Name:
- Valeric acid
- Cas Number:
- 109-52-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- pentanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Valeric acid, substance ID: 77/505
- Physical state: clear liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Mean weight at study initiation: male: 30 g; female: 24 g
- Fasting period before study: no data
- Housing: groups of five
- Diet: ad libitum
- Water: Tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Doses:
- 21.5, 100, 200, 464, 700, 2150 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females (200 and 700 mg/kg bw)
2 males and 2 females all other dosing groups - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily on working days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 464 mg/kg bw
- Mortality:
- 21.5 mg/kg dosing group: no death occurred
100 mg/kg dosing group: no death occurred
200 mg/kg dosing group: no death occurred
464 mg/kg dosing group: all animals died
700 mg/kg dosing group: all animals died within 7 days
2150 mg/kg dosing group: all animals died within 7 days - Clinical signs:
- dyspnoea, apathy, abdominal position, staggering, spastic gait, exsiccosis, bad general condition
- Body weight:
- normal body weight gain
- Gross pathology:
- Organs without findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
