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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study initiation date: 13. October 2009 Study completion date: 02. March 2010
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other:
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Valeric acid
EC Number:
203-677-2
EC Name:
Valeric acid
Cas Number:
109-52-4
Molecular formula:
C5H10O2
IUPAC Name:
pentanoic acid
Details on test material:
- Analytical purity (GC): 99,52 % [m/m]
- Purity test date: 11/18/2008
- Source: MV 1065
- Sampling date: 07/22/2007
- Lot/LIMS-ID: 20090825092241

Results and discussion

Dissociating properties:
yes
Dissociation constant
No.:
#1
pKa:
4.8
Temp.:
22.5 °C

Applicant's summary and conclusion

Conclusions:
The dissociation constant of the test item was determined according to OECD guideline no. 112
[adopted on 12 May 1981] with the titration method.
Dissociation constant (at 22.5 °C): pKA = 4.8

The test(s) used to generate this report was(were) carried out in compliance with the principles of Good Laboratory Practice (GLP) in accordance with the currently valid German Chemical Substance Act (Chemikaliengesetz – ChemG), the underlying Commission Directive 2004/10/EC of 11 February 2004 and the relevant OECD decision of the council on 26 November 1997 and that the results fully reflect those found in the study.
Executive summary:

The dissociation constant of the test item was determined according to OECD guideline no. 112

[adopted on 12 May 1981] with the titration method.

Dissociation constant (at 22.5 °C): pKA = 4.8