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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: BASF-Test to assess skin irritation or corrosivity in rabbits
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Valeric acid
EC Number:
203-677-2
EC Name:
Valeric acid
Cas Number:
109-52-4
Molecular formula:
C5H10O2
IUPAC Name:
pentanoic acid
Details on test material:
- Name of test material (as cited in study report): Valeric acid, substance ID: 77/505
- Physical state: clear liquid
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler
- Mean weight at study initiation: 3.4 kg
- Housing: individual
- Diet: Sniff ad libitum
- Water: ad libitum

Test system

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): cotton cloth soaked with the test material
- Concentration (if solution): undiluted
Duration of treatment / exposure:
3 min and 4 hours
Observation period:
8 days
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: 2 x 2 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol concentrated and Lutrol diluted to 50%
- Time after start of exposure: after 3 min and 4 hours, respectively

SCORING SYSTEM: the original scoring system was converted into Draize scores according to OECD

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Remarks:
animals 1-2
Time point:
other: 24, 48, 72 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: exposure period: 3 min
Irritation parameter:
edema score
Basis:
mean
Remarks:
animals 1-2
Time point:
other: 24, 48, 72 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: exposure period: 3 min
Irritation parameter:
erythema score
Basis:
mean
Remarks:
animals 1-2
Time point:
other: 24, 48, 72 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: exposure period: 4 hours
Irritation parameter:
edema score
Basis:
mean
Remarks:
animals 1-2
Time point:
other: 24, 48, 72 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: exposure period: 4 hours
Irritant / corrosive response data:
Full thickness necrosis observed in all animals exposed for 3 min and 4 hours to the test substance.

Any other information on results incl. tables

 

Readings

Animal

Exposure period: 3 min

Erythema

Edema

Additional findings

3 min

1

2

0

 

2

2

0

 

24 h

1

4

2

soft to parchment-like necrosis

2

4

2

parchment-like necrosis

48 h

1

4

2

parchment-like necrosis

2

4

2

parchment-like necrosis

72 h

1

4

2

parchment-like necrosis, desquamation,

2

4

2

parchment-like to leather-like necrosis

8 d

1

4

2

leather-like hard necrosis, 

2

4

1

leather-like hard necrosis, 

Mean 24, 48, 72 h

1

4

2

 

2

4

2

 

Mean 24, 48, 72 h

1-2

4

2

 

 

  

Readings

Animal

Exposure period: 4 hours

Erythema

Edema

Additional findings

4 h

1

4

2

 

2

4

2

 

24 h

1

4

2

parchment-like necrosis

2

4

2

parchment-like necrosis

48 h

1

4

2

parchment-like necrosis

2

4

2

parchment-like necrosis

72 h

1

4

2

parchment-like to leather-like necrosis

2

4

2

parchment-like to leather-like necrosis

8 d

1

4

2

leather-like hard necrosis, 

2

4

2

leather-like hard necrosis, 

Mean 24, 48, 72 h

1

4

2

 

2

4

2

 

Mean 24, 48, 72 h

1-2

4

2

 

*

 

Leather-like or hard necroses represent so-called full-thickness necroses involving all layers of the skin. Such necroses are relevant for classification representing a chemical being corrosive to the skin.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Valeric acid is corrosive to rabbit skin.