Valeric acid

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1987

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: BASF-Test to assess skin irritation or corrosivity in rabbits

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Valeric acid

EC Number:

203-677-2

EC Name:

Valeric acid

Cas Number:

109-52-4

Molecular formula:

C5H10O2

IUPAC Name:

pentanoic acid

Details on test material:

- Name of test material (as cited in study report): Valeric acid, substance ID: 77/505
- Physical state: clear liquid
- Analytical purity: no data

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler
- Mean weight at study initiation: 3.4 kg
- Housing: individual
- Diet: Sniff ad libitum
- Water: ad libitum

Test system

Type of coverage:

open

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

yes, concurrent no treatment

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): cotton cloth soaked with the test material
- Concentration (if solution): undiluted

Duration of treatment / exposure:

3 min and 4 hours

Observation period:

8 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2 x 2 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol concentrated and Lutrol diluted to 50%
- Time after start of exposure: after 3 min and 4 hours, respectively

SCORING SYSTEM: the original scoring system was converted into Draize scores according to OECD

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Remarks:

animals 1-2

Time point:

other: 24, 48, 72 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: exposure period: 3 min

Results 2

Irritation parameter:

edema score

Basis:

mean

Remarks:

animals 1-2

Time point:

other: 24, 48, 72 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: exposure period: 3 min

Results 3

Irritation parameter:

erythema score

Basis:

mean

Remarks:

animals 1-2

Time point:

other: 24, 48, 72 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: exposure period: 4 hours

Results 4

Irritation parameter:

edema score

Basis:

mean

Remarks:

animals 1-2

Time point:

other: 24, 48, 72 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: exposure period: 4 hours

Irritant / corrosive response data:

Full thickness necrosis observed in all animals exposed for 3 min and 4 hours to the test substance.

Any other information on results incl. tables

 

Readings	Animal	Exposure period: 3 min
		Erythema	Edema	Additional findings
3 min	1	2	0
	2	2	0
24 h	1	4	2	soft to parchment-like necrosis
	2	4	2	parchment-like necrosis
48 h	1	4	2	parchment-like necrosis
	2	4	2	parchment-like necrosis
72 h	1	4	2	parchment-like necrosis, desquamation,
	2	4	2	parchment-like to leather-like necrosis
8 d	1	4	2	leather-like hard necrosis,
	2	4	1	leather-like hard necrosis,
Mean 24, 48, 72 h	1	4	2
	2	4	2
Mean 24, 48, 72 h	1-2	4	2

 

  

Readings	Animal	Exposure period: 4 hours
		Erythema	Edema	Additional findings
4 h	1	4	2
	2	4	2
24 h	1	4	2	parchment-like necrosis
	2	4	2	parchment-like necrosis
48 h	1	4	2	parchment-like necrosis
	2	4	2	parchment-like necrosis
72 h	1	4	2	parchment-like to leather-like necrosis
	2	4	2	parchment-like to leather-like necrosis
8 d	1	4	2	leather-like hard necrosis,
	2	4	2	leather-like hard necrosis,
Mean 24, 48, 72 h	1	4	2
	2	4	2
Mean 24, 48, 72 h	1-2	4	2

*

 

Leather-like or hard necroses represent so-called full-thickness necroses involving all layers of the skin. Such necroses are relevant for classification representing a chemical being corrosive to the skin.

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Valeric acid is corrosive to rabbit skin.