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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study only available as summary in the ECB iuclid dataset for 3-chloropropane-1,2-diol (European Commission-European Chemicals Bureau-19 Feb 2000-http://ecb.jrc.eu/esis/index.php?GENRE=CASNO&ENTREE=9624-2).

Data source

Reference
Title:
Alpha-chlorohydrin-induced changes in|the distribution of free myo-inositol and prostaglandin|F2alpha, and synthesis of phosphatidylinositol in the rat|epididymis
Author:
Voglmayr J.K.
Year:
1974
Bibliographic source:
Biol. Reprod., 11, 593-600.

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloropropane-1,2-diol
EC Number:
202-492-4
EC Name:
3-chloropropane-1,2-diol
Cas Number:
96-24-2
Molecular formula:
C3H7ClO2
IUPAC Name:
3-chloropropane-1,2-diol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
5 and 20 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
40 and 7 mg/kg/day resp.
Control animals:
yes

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Increased concentrations of inositol (In) and prostaglandin
F2alpha (Pr) were found in the cauda of rats treated with
40 mg/kg/day for 5 days. These rats showed no effects on the
In concentration of testes and caput epididymides and on the
Pr contents of caput epididymides.
  No measurable changes of the In concentrations of the
reproductive tract and of the glucose incorporation in
spermatozoal lipids of rats were found after the treatment
with 7 mg/kg/day for 20 days.

Applicant's summary and conclusion