Registration Dossier
Registration Dossier
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EC number: 200-830-5 | CAS number: 75-00-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - May 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- secondary source
- Title:
- Chloroethane CAS: 75-00-3
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 22
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Chloroethane
- EC Number:
- 200-830-5
- EC Name:
- Chloroethane
- Cas Number:
- 75-00-3
- Molecular formula:
- C2H5Cl
- IUPAC Name:
- chloroethane
- Details on test material:
- - Name of test material (as cited in study report): chloroethane
- Physical state: gaseous
- Analytical purity: > 99.5% (Matheson Gas Products, East Rutherford, NJ, USA)
- Lot/batch No.: 44480
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Portage, MI, USA)
- Age at study initiation: 9-10 weeks
- Housing: individually in stainless steel wire cages (Harford Metal Inc., Aberdeen, MD, USA)
- Diet: NIH 07 rat and mouse ration (Zeigler Bros., Inc., Gardners, PA, USA) available ad libitum during non-exposure periods
- Water: automatic watering system (Edstrom Industries, Waterford, WI, USA), available ad libitum
- Acclimation period: 26 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): exposure: 23.9 - 24.4 °C; non-exposure: 22.2 - 24.4 °C
- Humidity (%): exposure: 55 - 57%; non-exposure: 40 - 60%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: April 1980 To: 12 May 1980
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: vapour generation system; the liquid to be vaporized was forced under pressure, at a metered rate, directly from the shipping container into a stainless steel boiler that was maintained at about 32 °C by a controlled-temperature water bath. The vapour was routed through a gas metering valve and a purge/expose valve into a pipe at the chamber inlet, where the vapour was mixed with dilution air entering the chamber.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 19000 ppm (50130 mg/m3)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed continually during exposure and then 3 times per day for 14 days; weighed initially
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 19 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- All mice survived.
- Clinical signs:
- other: No clinical signs of toxicity were seen.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Executive summary:
Groups of male and female mice (5/sex) were exposed by whole body inhalation for a single 4-hour exposure to air containing chloroethane at the target concentration of 19000 ppm (National Toxicology Program, 1989). Animals were weighed before exposure and were observed continually during exposure and then three times per day for 14 days. After 14 days, the animals were killed without a formal necropsy. All mice survived the 4-hour exposure to 19000 ppm chloroethane. No clinical signs of toxicity were seen.
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