Registration Dossier
Registration Dossier
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EC number: 200-830-5 | CAS number: 75-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Standard sensitisation testing is not feasible for chloroethane since it is a gas.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Standard skin sensitisation testing is not applicable to chloroethane as it exists as a gas.
There are no data available of the sensitizing action of chloroethane in animals.
A case of sensitisation after use of a chloroethane spray was reported in a 66-year old woman, who showed severe and peculiar pattern of eczematous reactions after local anaesthesia with chloroethane spray to remove mollusca contagiosa. Patch tests were performed, examining that the patient suffered from a sensitisation to chloroethane (Aberer and Zonzits, 1989).
Van Ketel (1976) performed patch tests on two patients with eczema. The patch tests were strongly positive for chloroethane, while a third patient suffered an eczematous reaction after the use of chloroethane as a local anaesthetic, indicating that sensitisation to chloroethane can occur. Patch tests on 15 control volunteers were negative.
A punch biopsy taken from a woman with a positive patch test to chloroethane revealed observations consistent with a T-cell-mediated sensitisation reaction (Bircher et al., 1994). Microscopic examination showed marked spongiosis and a lymphohistocytic infiltrate. There was a marked dermal infiltrate of CD3+ T cells (pan T cells), with predominance of CD4+ T cells (helper/suppressor cell subtypes). Most of the cells expressed lymphocyte function-associated antigen. A considerable number of CD1+ Langerhans cells were also found in the epidermis.
However, in view of the frequent use of chloroethane in the past, these effects are probably rare cases.
References:
Bircher, A.J. et al. (1994) Allergic contact dermatitis from ethyl chloride and sensitization to dichlorodifluoromethane. Contact Dermatitis31:41-44 (as cited in ATSDR, 1998)
Van Ketel, W.G. (1976) Allergic contact dermatitis from propellants in deodorant sprays in combination with allergy to ethyl chloride. Contact Dermatitis 2: 115-119 (as cited in ATSDR, 1998)
ATSDR (1998) Toxicological Profile for Chloroethane. U.S. Department of Health and human services, Public Health Service, Agency for Toxic Substances and Disease Registry
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The data is inconclusive.
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