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EC number: 200-830-5 | CAS number: 75-00-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 AUG - 26 AUG 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Ethylchlorid was given in excess in VE-water. The vessel was closed with a septum and incubated over 4 days at 4°C.
Preparation of test concentrations: head-space-vessels of 20 mL volume were filled with 19 mL synthetic freshwater and closed with as septum. All used instruments were cooled to 8°C. Adequate amounts of the stock solution were injected to each of the test vessels. The whole process was conducted at 8°C
- Controls: water control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: waterflea
- Strain: clon 5
- Source: in-house culture
- Age at study initiation (mean and range, SD): below 24 h
- Method of breeding: parent daphnids were cultivated in Elendt medium in 1 L glass beakers. Animals were fed daily with Scenedesmus subspicatus.
- Feeding during test: no feeding - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 +/- 1 °C
- pH:
- 7.0 - 7.2 at test end
- Dissolved oxygen:
- 8.3 - 8.6 at test end
- Nominal and measured concentrations:
- nominal: 0, 10, 20, 40, 80, 160 and 320 mg/L
mean measured: 0, 5.7, 11.1, 24.5, 46.5, 91, 217 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: round-bottom flasks filled with 10 mL test solution
- Aeration: none
- Type of flow-through (e.g. peristaltic or proportional diluter): static test
- No. of organisms per vessel: approximately 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 4 mL per test organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: synthetic freshwater. Composition: 294 mg/L CaCl2 x 2H2O; 123 mg/L MgSO4 x 7 H2O, 63 mg/L NaHCO3 and 5.5 mg/L KCl
- Ca/mg ratio: 4 : 1
- Intervals of water quality measurement: 48 h
OTHER TEST CONDITIONS
- Photoperiod: continuous darkness - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate was tested in a separate study
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 58 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% C.L. 44 mg/L - 77 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 91 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- Mortality: 0.9 mg/L - 25% immobile daphnids after 24 h; 1.9 mg/L - 100% immobile daphnids after 24 h
Reference
Mean measured concentration |
Test period (h) |
|
24 h |
48 h |
|
Immobility [%] |
Immobility [%] |
|
0 |
0 |
0 |
5.7 |
0 |
0 |
11.1 |
5 |
5 |
24.5 |
0 |
7 |
46.5 |
15 |
20 |
91 |
50 |
85 |
217 |
100 |
100 |
Description of key information
EC50(48 h): 58 mg/L (meas. geom. mean)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 58 mg/L
Additional information
The acute toxicity of chloroethane (CAS 75-00-3) to aquatic invertebrates was tested in a guideline study following EU method C2. Daphnia magna were exposed to measured test concentrations of 5.7, 11.1, 24.5, 46.5, 91 and 217 mg/L under static conditions. The test concentrations were prepared by giving ethylchlorid in excess in VE-water. The vessel was closed with a septum and incubated over 4 days at 4°C. The test concentrations were prepared by filling head-space-vessels (20 mL volume) with 19 mL synthetic freshwater. The vessels were closed with a septum. At test termination an EC50 (48 h) of 58 mg/L (measured, geom. mean) were determined.
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