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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Electrocardiographic changes during ethyl chloride and vinyl ether anesthesia in the dog and man
Author:
Bush, O.F. et al.
Year:
1952
Bibliographic source:
Anesthesiology 13:197-202
Reference Type:
secondary source
Title:
Chloroethane CAS: 75-00-3
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for SIAM 22

Materials and methods

Study type:
not specified
Endpoint addressed:
acute toxicity: inhalation
Principles of method if other than guideline:
Eighteen unoperated persons (5-12 years old) were anaesthesized with chloroethane and electrocardiographic tracings were taken. In the first study the subjects were premedicated with atropine, which prevents vagal inhibition. In a second study the same subjects were anaesthesized without pre-anaesthetic medication with the anticholinergic drug.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethane
EC Number:
200-830-5
EC Name:
Chloroethane
Cas Number:
75-00-3
Molecular formula:
C2H5Cl
IUPAC Name:
chloroethane
Details on test material:
- Name of test material (as cited in study report): ethyl chloride
- Analytical purity: no data

Method

Type of population:
not specified
Subjects:
- Number of subjects exposed: 18
- Sex: no data
- Age: 5-12 years
- Other: unoperated
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
Anaesthesia was inducted and maintained by the open drop technic throughout the entire course of anaesthesia.

Results and discussion

Clinical signs:
No notable changes in the electrocardiographic records were observed in the first study with atropine administration. In the second study early vagal inhibitions appeared as observed in dog experiments. Chloroethane was immediately discontinued and 0.25 mg atropine was given i.v.. Reversal of the vagal inhibition occurred within twenty or more seconds. Trachycardia followed, which was probably the result of loss of vagal tone.

Applicant's summary and conclusion