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Landry et al. (1982 and 1989) investigated the neurophysiological and behavioural parameters after chloroethane exposure in Beagle dogs and B6C3F1 mice.
Male Beagle dogs (2 animals per dose) were exposed up to 10000 ppm chloroethane, 6 hours/day, 5 days/week for 14 days. Neurologic examinations (gait, posture, cranial nerve reflexes, postural reactions, spinal cord reflexes, muscle tone and pain perception) were performed on all dogs, but no neurologic abnormalities were observed in the treated or control groups.
Mice were exposed continuously for 11 days, 23 hours/day up to 5000 ppm chloroethane. A blind neurobehavioral observation battery was conducted on the 12thday. No apparent signs of toxicity either during routine observation or with the neurobehavioral observational battery were reported.
Brain weight and brain or peripheral nerve histopathology were not affected in both species.

 

In humans, reversible neurological changes like ataxia, nystagmus, stammering and dysbasia following chronic abuse (sniffing) have been described (Nordin et al., 1988; Hes et al., 1979).

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