Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Allergy to ethyl chloride does occur, and might frequently be misdiagnosed.
Author:
Aberer, W. and Zonzits, E.
Year:
1989
Bibliographic source:
Contact Dermatitis 21:352-353

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: case report and study with volunteer
Principles of method if other than guideline:
Chlorothane spray anaesthesia was used to remove mollusca contagiosa in a 66-year old woman. 36 hours later, a severe and peculiar pattern of eczematous reactions occurred in the areas of treatment, with accentuation at the borders and where the spray had run down the flank. Patch test was performed with chloroethane and freons.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethane
EC Number:
200-830-5
EC Name:
Chloroethane
Cas Number:
75-00-3
Molecular formula:
C2H5Cl
IUPAC Name:
chloroethane
Details on test material:
- Name of test material (as cited in study report): ethyl chloride
- Analytical purity: no data

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 1
- Sex: female
- Age: 66 years
Controls:
no controls
Route of administration:
dermal

Results and discussion

Results of examinations:
The patch test showed, that the patient suffered from a skin sensitization to chloroethane. Severe eczematous reactions erupted around the sprayed areas in all instances. Treatment with steroid ointment brought quick relief.

Applicant's summary and conclusion