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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Work pre-dates guidelines and GLPs, Limited documentation, list published in peer-reviewed journal. 24-hour exposure
Justification for type of information:
Work pre-dates guidelines and GLPs, Limited documentation, list published in peer-reviewed journal. 24-hour exposure

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Primary irritation on rabbits was recorded in a 10-grade ordinal series based on the severest reaction that developed on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of the test sample.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
3,3',3''-(1,3,5-triazinane-1,3,5-triyl)tris(N,N-dimethylpropan-1-amine)
Test material form:
other: 85% aqueous solution
Details on test material:
85% aqueous solution of N,N-(dimethylaminopropyl)-s-hexahydrotriazine

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
open
Preparation of test site:
clipped
Amount / concentration applied:
0.01 ml
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
5

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: Unknown. List entry.
Time point:
24 h
Score:
>= 5
Max. score:
5
Reversibility:
not specified
Irritant / corrosive response data:
Following a 24-hour open exposure the material was irritating but not corrosive. Score of 5 out of 10.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The material is irritating to the skin following a 24-hour open exposure.
Executive summary:

The material is irritating to the skin following a 24-hour open exposure. Graded a 5 out of 10.