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EC number: 240-004-1 | CAS number: 15875-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Evaluation of the existing studies
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Performed by the GLP laboratory experts.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Evaluation of the existing studies and available data.
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- EC Number:
- 240-004-1
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- Cas Number:
- 15875-13-5
- Molecular formula:
- C18H42N6
- IUPAC Name:
- (3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
- IUPAC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
- Test material form:
- liquid: viscous
- Details on test material:
- Test material details are described under each relevant text.
Constituent 1
Constituent 2
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The relatively small molecular weight (343 Daltons) and the high water solubility (500 g/L) are particularly favorable for absorption from the gut. In addition, the low log Pow value (0.26 to 0.18) is favorable for absorption by passive diffusion.
- Type:
- distribution
- Results:
- The small molecular weight and high water solubility are favorable for distribution throughout the body.
- Type:
- metabolism
- Results:
- The results of repeated dose studies indicate that the substance either has limited absorption/ penetration into the body or it was rapidly removed (metabolized or excreted) from the body.
- Type:
- excretion
- Results:
- Small molecular weight, high water solubility and low log Pow are favorable for excretion. This material has a low bioaccumulation potential.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other:
Results of the toxicokinetic evaluation shows that substance N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine is practically non-toxic, does not appear to penetrate into the body of experimental animals and its toxic effects are manifested only on local level. - Executive summary:
From information from acute toxicity studies it seems that the substance N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine either had limited absorption/ penetration into the body or it was rapidly removed (metabolized or excreted) from the body. Toxic effects were manifested only on local level (irritation of skin and mucous membranes) Also the results of sensitisation studies (no sensitisation, potential skin irritation) support this conclusion. Result of acute oral toxicity testing is that the substance is practically non-toxic. After repeated oral exposition subtle changes in some biochemical and haematological parameters were detected but those were not attributable to the test substance effect. Only pathological changes in forestomach could be considered as attributable to the test substance action. These findings lead to the conclusion that also in this case the substance did not enter the animal body and its effect is manifested only locally in the site of first contact with organism, in forestomach. With respect to reproduction toxicity parameters it is not possible to confirm penetration through the placental barrier. The test substance did not affect the reproduction of animals and development of pups. No studies or specific information about metabolism, distribution and excretion of the test substance were found.
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