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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Work pre-dates guidelines and GLPs, Limited documentation, published in peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
IUPAC Name:
N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
Constituent 2
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
3,3',3''-(1,3,5-triazinane-1,3,5-triyl)tris(N,N-dimethylpropan-1-amine)
Details on test material:
N-N'-N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine, 85% aqueous solution

Test animals

Species:
rabbit

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2.02 mL/kg bw
95% CL:
1.24 - 3.29
Remarks on result:
other: Based on a density of 0.912 mg/ml the LD50 would be 1842 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
Executive summary:

The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.