N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Work pre-dates guidelines and GLPs, Limited documentation, published in peer-reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1974

Materials and methods

Principles of method if other than guideline:

Method: other: no data

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine

IUPAC Name:

N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine

Constituent 2

Reference substance name:

N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine

EC Number:

240-004-1

EC Name:

N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine

Cas Number:

15875-13-5

Molecular formula:

C18H42N6

IUPAC Name:

(3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine

Details on test material:

N-N'-N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine, 85% aqueous solution

Test animals

Species:

rabbit

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2.02 mL/kg bw

95% CL:

1.24 - 3.29

Remarks on result:

other: Based on a density of 0.912 mg/ml the LD50 would be 1842 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.

Executive summary:

The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.