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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Work pre-dates guidelines and GLPs, Limited documentation, published in peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
IUPAC Name:
N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
Constituent 2
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
(3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
Details on test material:
N-N'-N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine, 85% aqueous solution

Test animals

Species:
rabbit

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2.02 mL/kg bw
95% CL:
1.24 - 3.29
Remarks on result:
other: Based on a density of 0.912 mg/ml the LD50 would be 1842 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
Executive summary:

The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.