Registration Dossier
Registration Dossier
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EC number: 240-004-1 | CAS number: 15875-13-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The material has a low log Kow in the range of 0.26 to 0.18 so bioaccumulation is not expected. Tests in multiple species demonstrate minimal or no systemic toxicity. Primarily local effects (irritation of the skin, stomach, and mucous membranes) were seen. This suggests that absorbtion into the body is minimal.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The material has a low log Kow in the range of 0.26 to 0.18 so bioaccumulation is not expected. Tests in multiple species demonstrate minimal or no systemic toxicity. Primarily local effects (irritation of the skin, stomach, and mucous membranes) were seen. This suggests that absorbtion into the body is minimal.
Dermal absorption of low molecular weight (< 500 Daltons) substances with log Pow between -1 and 4 is anticipated. These compounds are also expected to be well absorbed in the respiratory and gastro-intestinal tracts.
The water solubility of the substance favors extensive and even systemic distribution via the circulatory system.
There is a commonality in the metabolism of the tertiary amines. N-oxide formation and excretion of both freebase and N-oxide forms, with some dealkylation, appears to be the major route of excretion for the lower molecular weight tertiary amines.
QSAR indicates extensive metabolism; the production of a number of highly water-soluble metabolites favors urinary excretion and indicates that bioaccumulation is unlikely.
Since the physical-chemical properties of this material favor absorption and the material is relatively non-toxic to aquatic and mammalian organisms, it is believed that this material is rapidly detoxified and or excreted unchanged from the body.
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