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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-dates guidelines and GLPs, limited documentation, published in peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Single oral dose toxicity is estimated by gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4-5 weeks of age and weighing 90 to 120 grams. Doses were arranged in logarithmic series differing by a factor of two. Based upon mortalities during a 14-day observation period, the most probable LD50 and its 95% confidence limits are estimated by the method of Thompson and Weil.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
3,3',3''-(1,3,5-triazinane-1,3,5-triyl)tris(N,N-dimethylpropan-1-amine)
Constituent 2
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
IUPAC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
Test material form:
liquid: viscous
Details on test material:
Air Products and Chemicals, Inc. Polycat 41, Batch 1700082

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.25 mL/kg bw
Based on:
other: 85% aqueous solution
95% CL:
2.36 - 4.47
Remarks on result:
other: Based on a density of 0.912 mg/ml the LD50 would be 2964 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
Executive summary:

The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw