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EC number: 240-004-1 | CAS number: 15875-13-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-dates guidelines and GLPs, limited documentation, published in peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- Single oral dose toxicity is estimated by gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4-5 weeks of age and weighing 90 to 120 grams. Doses were arranged in logarithmic series differing by a factor of two. Based upon mortalities during a 14-day observation period, the most probable LD50 and its 95% confidence limits are estimated by the method of Thompson and Weil.
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- EC Number:
- 240-004-1
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- Cas Number:
- 15875-13-5
- Molecular formula:
- C18H42N6
- IUPAC Name:
- (3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
- IUPAC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
- Test material form:
- liquid: viscous
- Details on test material:
- Air Products and Chemicals, Inc. Polycat 41, Batch 1700082
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.25 mL/kg bw
- Based on:
- other: 85% aqueous solution
- 95% CL:
- 2.36 - 4.47
- Remarks on result:
- other: Based on a density of 0.912 mg/ml the LD50 would be 2964 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
- Executive summary:
The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
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