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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-dates guidelines and GLPs, limited documentation, published in peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Single oral dose toxicity is estimated by gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4-5 weeks of age and weighing 90 to 120 grams. Doses were arranged in logarithmic series differing by a factor of two. Based upon mortalities during a 14-day observation period, the most probable LD50 and its 95% confidence limits are estimated by the method of Thompson and Weil.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
(3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
Constituent 2
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
IUPAC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazin-1,3,5(2H,4H,6H)-tripropanamine
Test material form:
liquid: viscous
Details on test material:
Air Products and Chemicals, Inc. Polycat 41, Batch 1700082

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.25 mL/kg bw
Based on:
other: 85% aqueous solution
95% CL:
2.36 - 4.47
Remarks on result:
other: Based on a density of 0.912 mg/ml the LD50 would be 2964 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
Executive summary:

The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw