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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: study report which meets basic scientific principles, acceptable with restrictions (limited documentation)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975
Reference Type:
other company data
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(adopted 1981)
Deviations:
yes
Remarks:
no analytical verification of test substance concentration
Principles of method if other than guideline:
This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20 °C and 1002.6 hPa).
Several groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder containing approximately 120 mL test substance for 8 hours. Compressed air without further filtering was used in order to generate the test substance atmosphere. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, which was given in the raw data, and the amount of air used during the exposure. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
EC Number:
240-004-1
EC Name:
N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
Cas Number:
15875-13-5
Molecular formula:
C18H42N6
IUPAC Name:
3,3',3''-(1,3,5-triazinane-1,3,5-triyl)tris(N,N-dimethylpropan-1-amine)
Details on test material:
Name of the test substance used in the study report: Triazin (= HM 17 994).
Analytical purity: no data.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Mean body weight of animals before beginning of exposure:
- males: 177 g (test group 1); 186 g (test group 2);
- females: 173 g (test group 1); 170 g (test group 2).

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Inhalation of an atmosphere enriched with vapour at 20°C. For enrichment, 200 L air/h was conducted through a Iayer of about 5 cm of the product.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Mean concentration: 0.51 mg/L
No. of animals per sex per dose:
3 animals/sex/dose in one group (two groups are used)
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
0.51 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: IHT: No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound.
Mortality:
none
Clinical signs:
other: none
Gross pathology:
Sacrificed animals: nothing abnormal detected.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Inhalation EC50 (8-hour) of the substance in rats was determined to be > 0.51 mg/l. No mortality or abnormal clinical signs were observed at this concentration.
Executive summary:

Inhalation EC50 (8-hour) of the substance in rats was determined to be > 0.51 mg/l. No mortality or abnormal clinical signs were observed at this concentration.