Reaction mass of 1,3-dioxane-5,5-dimethanol and 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]-

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 11 SEP to 16 SEP 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

no

Remarks:

Proprietary study conducted by Perstorp Holding AB according to OECD test guideline

Radiolabelling:

no

Analytical monitoring:

yes

Buffers:

pH 4.0 (citric acid/ sodium hydroxide/hydrogen chloride) , pH 7.0 (di-sodium hydrogen phosphate/ potassium di-hydrogen phosphate) and pH 9.0 (boric acid/ potassium chloride/ sodium hydrogen) buffer solutions were used.

Estimation method (if used):

Not required.

Details on test conditions:

80 mg Polyol PX was dissolved in 25 mL water. 5 mL of this stock solution was added to 10 mL buffer solutions. One part of each buffer solution was put in the freezer (-20 °C) as a reference and the other part put in a heating cabinet at 50 °C for 5 days.

Duration:

5 d

pH:

4

Temp.:

50 °C

Duration:

5 d

pH:

7

Temp.:

50 °C

Duration:

5 d

pH:

9

Temp.:

50 °C

Number of replicates:

2 per buffer

Positive controls:

no

Preliminary study:

A preliminary test was performed at 50°C and pH 4.0, 7.0 and 9.0.

Test performance:

No information.

Transformation products:

no

Details on hydrolysis and appearance of transformation product(s):

At pH 4.0, the pentaerythritol peak co-elutes with the peak from the salt in the buffer solution, therefore, no results have been given.

Key result

pH:

4

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Key result

pH:

7

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Key result

pH:

9

Temp.:

50 °C

Remarks on result:

hydrolytically stable based on preliminary test

Details on results:

Polyol PX is a multicomponent product consisting on MPE, CPF and PFM. Recovery was reported as the % change based on the individual components and not on Polyol PX.

Results quoted as the average of two weighings.

MPE

	MPE (-20 °C) mg/mL	MPE (50 °C) mg/mL	Change %
pH 4	-*	-*	-*
pH 7	0.0365	0.0370	0.45
pH 9	0.0180	0.0185	2.25

-* MPE peak co-eluted with the peak from the salt in the buffer solution

CPF

	CPF (-20 °C) mg/mL	CPF (50 °C) mg/mL	Change %
pH 4	0.590	0.635	7.75
pH 7	0.630	0.635	0.35
pH 9	0.640	0.635	-0.85

PFM

	PFM (-20 °C) mg/mL	PFM (50 °C) mg/mL	Change %
pH 4	0.094	0.103	9.70
pH 7	0.110	0.110	-2.60
pH 9	0.115	0.115	1.55

Validity criteria fulfilled:

not specified

Conclusions:

No significant hydrolysis was detected in any of the buffer systems investigated.

Executive summary:

No significant levels of hydrolysis were detected at any of the pH values tested (i.e. hydrolysis was less than the trigger value of 10%) after 5 days at each pH 4, 7 and 9, indicating a hydrolysis half-life of greater than 1 year at environmentally relevant temperature i.e. 20 °C (the substance is stable to hydrolysis at all pH's).

This result suggests that hydrolysis will not be a significant pathway of degradation for Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol in the environment.

Description of key information

All of the components in Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2 [(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol are stable to hydrolysis i.e. the estimated half-life of the components is greater than one year under typical environmental conditions.

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

50 °C