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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 11 SEP to 16 SEP 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
no
Remarks:
Proprietary study conducted by Perstorp Holding AB according to OECD test guideline
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
pH 4.0 (citric acid/ sodium hydroxide/hydrogen chloride) , pH 7.0 (di-sodium hydrogen phosphate/ potassium di-hydrogen phosphate) and pH 9.0 (boric acid/ potassium chloride/ sodium hydrogen) buffer solutions were used.
Estimation method (if used):
Not required.
Details on test conditions:
80 mg Polyol PX was dissolved in 25 mL water. 5 mL of this stock solution was added to 10 mL buffer solutions. One part of each buffer solution was put in the freezer (-20 °C) as a reference and the other part put in a heating cabinet at 50 °C for 5 days.
Duration:
5 d
pH:
4
Temp.:
50 °C
Duration:
5 d
pH:
7
Temp.:
50 °C
Duration:
5 d
pH:
9
Temp.:
50 °C
Number of replicates:
2 per buffer
Positive controls:
no
Preliminary study:
A preliminary test was performed at 50°C and pH 4.0, 7.0 and 9.0.
Test performance:
No information.
Transformation products:
no
Details on hydrolysis and appearance of transformation product(s):
At pH 4.0, the pentaerythritol peak co-elutes with the peak from the salt in the buffer solution, therefore, no results have been given.
Key result
pH:
4
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Details on results:
Polyol PX is a multicomponent product consisting on MPE, CPF and PFM. Recovery was reported as the % change based on the individual components and not on Polyol PX.

Results quoted as the average of two weighings.

MPE

 

MPE (-20 °C)

mg/mL

MPE (50 °C)

mg/mL

Change

%

pH 4

-*

-*

-*

pH 7

0.0365

0.0370

0.45

pH 9

0.0180

0.0185

2.25

-* MPE peak co-eluted with the peak from the salt in the buffer solution

CPF

 

CPF (-20 °C)

mg/mL

CPF (50 °C)

mg/mL

Change

%

pH 4

0.590

0.635

7.75

pH 7

0.630

0.635

0.35

pH 9

0.640

0.635

-0.85

PFM

 

PFM (-20 °C)

mg/mL

PFM (50 °C)

mg/mL

Change

%

pH 4

0.094

0.103

9.70

pH 7

0.110

0.110

-2.60

pH 9

0.115

0.115

1.55

Validity criteria fulfilled:
not specified
Conclusions:
No significant hydrolysis was detected in any of the buffer systems investigated.
Executive summary:

No significant levels of hydrolysis were detected at any of the pH values tested (i.e. hydrolysis was less than the trigger value of 10%) after 5 days at each pH 4, 7 and 9, indicating a hydrolysis half-life of greater than 1 year at environmentally relevant temperature i.e. 20 °C (the substance is stable to hydrolysis at all pH's).

This result suggests that hydrolysis will not be a significant pathway of degradation for Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol in the environment.

Description of key information

All of the components in Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2 [(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol are stable to hydrolysis i.e. the estimated half-life of the components is greater than one year under typical environmental conditions.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
50 °C

Additional information