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Ecotoxicological information

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A 96 hour acute semi-static toxicity study in zebra fish (Brachydanio rerio) was performed to assess the toxicity of

Polyol PX. The study was performed according to GLP and the OECD 203 Test Guideline. The 96 hour LC50 was calculated to be 1800 mg/L (based nominal exposure concentrations), the corresponding NOEC was 800 mg/L (nominal concentration) (Olsson, 2008).

A static 48 hour definitive test was performed exposingDaphnia magnato a range of concentrations (500 - 4000 mg/L) of Polyol PX. The study was performed in accordance with the OECD guideline 202 and according to GLP. The 48 hour EC50 was calculated to be 2230 mg/L (based on nominal concentrations), the corresponding no-observed effect concentration was observed to be 1000 mg/L (Olsson, 2008).

A 72 hour algal growth inhibition study, test speciesSelenastrum capricornutum, was performed to determine the toxic effects of the test substance Polyol PX. The test was conducted according to OECD test guideline 201, and performed to GLP. Based on nominal exposure concentrations the 72 hour ErC50 was calculated to be 639 mg/L and the corresponding no-observed effect concentration (NOEC) was 250 mg/L. The 72 hour EyC50 was calculated to be 347 mg/L and the corresponding NOEC was 250 mg/L (Olsson, 2008).

The toxicity of Polyol PX to activated sewage sludge was investigated in a respiration inhibition test according to OECD test guideline 209. Following three hours exposure to Polyol PX the EC50 was observed to be > 1000 mg/L (based on nominal exposure concentrations), the corresponding NOEC was observed to 1000 mg/L.

In the chemical safety assessment performed according to Article 14(3) in connection with Annex I section 3 (Environmental Hazard Assessment) no hazard was identified. Therefore according to REACH Annex I (5.0) exposure estimation is not necessary for long-term toxicity to fish and aquatic invertebrates. Consequently, in accordance with Column 2 of REACH Annex IX, the study does not need to be conducted as all identified uses of the substance are assessed as safe for the environment.