Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Ketones of six to thirteen carbons
Author:
Topping, D.C., et al.
Year:
2001
Bibliographic source:
. In: Patty's toxicology. 5th ed. Edited by E. Bingham, et al. Vol. 6, Chpt. 76. John Wiley and Sons, 2001.Article online posting date: Apr. 16, 2001
Reference Type:
other: Authoritative data base
Title:
CHEMINFO Record Number: 4190
Year:
2011
Bibliographic source:
CHEMINFO ;Topping, D.C., et al. Ketones of six to thirteen carbons. In: Patty's toxicology. 5th ed. Edited by E. Bingham, et al. Vol. 6, Chpt. 76. John Wiley and Sons, 2001.Article online posting date: Apr. 16, 2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from Pattys handbook and Cheminfo
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
1-24 hours
Observation period (in vivo):
14 days

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days

Applicant's summary and conclusion

Interpretation of results:
other: mild irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days
Executive summary:

Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days.