Registration Dossier
Registration Dossier
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EC number: 223-453-8 | CAS number: 3900-45-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Ketones of six to thirteen carbons
- Author:
- Topping, D.C., et al.
- Year:
- 2 001
- Bibliographic source:
- . In: Patty's toxicology. 5th ed. Edited by E. Bingham, et al. Vol. 6, Chpt. 76. John Wiley and Sons, 2001.Article online posting date: Apr. 16, 2001
- Reference Type:
- other: Authoritative data base
- Title:
- CHEMINFO Record Number: 4190
- Year:
- 2 011
- Bibliographic source:
- CHEMINFO ;Topping, D.C., et al. Ketones of six to thirteen carbons. In: Patty's toxicology. 5th ed. Edited by E. Bingham, et al. Vol. 6, Chpt. 76. John Wiley and Sons, 2001.Article online posting date: Apr. 16, 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Pattys handbook and Cheminfo
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- IUPAC Name:
- benzophenone
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 1-24 hours
- Observation period (in vivo):
- 14 days
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days
- Executive summary:
Application of benzophenone crystals caused mild irritation in rabbits. Mild to moderate erythema occurred from 1-24 hours. The effects were reversed within 14 days.
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