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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
β-methyl naphthyl ketone
Author:
Opdyke DLJ
Year:
1975
Bibliographic source:
Food and Cosmetics Toxicology, Volume 13, Issue 6, Page 867

Materials and methods

Principles of method if other than guideline:
Maximization test
GLP compliance:
not specified
Type of study:
other: Maximization test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2'-acetonaphthone
- Substance type: Organic
- Physical state: Solid

In vivo test system

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: no data
Vehicle:
petrolatum
Concentration / amount:
2 %
Challenge
Concentration / amount:
2 %
No. of animals per dose:
25

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
Dose level:
2%
No. with + reactions:
0
Total no. in group:
25
Clinical observations:
no sensitization reactions
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 2%. No with. + reactions: 0.0. Total no. in groups: 25.0. Clinical observations: no sensitization reactions.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acetophenone was assessed as non-sensitiser in a Maximization test with humans.
Executive summary:

The maximization test was carried out on 25 volunteers. The material was tested at a concentration of 2% in petrolatum and produced no sensitization reactions.