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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

The substance 1-(6-methoxy-2-naphthyl)ethan-1-one is not genotoxic

Link to relevant study records
Reference
Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
QSAR prediction is done using the QSAR toolbox version 2.3
GLP compliance:
not specified
Type of assay:
in vitro mammalian chromosome aberration test
Species / strain / cell type:
other: Chinese Lung cell
Additional strain / cell type characteristics:
not specified
Metabolic activation:
without
Metabolic activation system:
S9
Species / strain:
other: chinese lung cell
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.





The prediction was based on dataset comprised from the following descriptors: "Chromosome aberration"
Estimation method: Taking highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(=O)c1cc2c(cc(OC)cc2)cc1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(C)(=O)c1cc2c(cc(OC)cc2)cc1
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.46

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.28

Conclusions:
Interpretation of results (migrated information):
negative

The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic.
Executive summary:

The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

Genetic toxicity

Based on studies of target substance CAS NO 3900-45-6 and read across reviewed for genetic toxicity from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach.

 

The summary of the results are presented below

 

Sr. No

End point

Effect

Species

 

Remarks

1

 chromosome aberration

negative without metabolic activation

 

chinese hamster lung cells

 

Predicted data of target chemical

2

 In vitro Genetic toxicity

 negative with metabolic activation

 

 S. typhimurium TA 100

Predicted data of target chemical

3

 In vitro Genetic toxicity

 

negative without metabolic activation

 S. typhimurium TA 100

 

Predicted data of target chemical

4

In vitro Genetic toxicity

negative with and without metabolic activation

S. typhimurium TA 1535, TA 1537, TA 98, TA1538 and TA 100

Data is from publication for CAS NO 93-08-3

5

In vitro Genetic toxicity

negative with and without metabolic activation

S. typhimurium TA 97, 8 and TA 102

Data is from publication for CAS NO 93-08-3

6

In vitro Genetic toxicity

negative with and without metabolic activation

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Data is from publication for CAS NO 93-04-9

 

Based on the results summarized in above table for the target chemical CAS NO 3900-45-6 and read across, it can be concluded that the substance is non-genotoxic.Thus according to CLP criteria 1-(6-methoxy-2-naphthyl) ethan-1-one is considered to be non-genetic toxic substance.

Justification for selection of genetic toxicity endpoint

The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic.

Justification for classification or non-classification

The subsatnce 1-(6-methoxy-2-naphthyl)ethan-1-one is not genotoxic as per CLP criteria