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EC number: 223-453-8 | CAS number: 3900-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The substance 1-(6-methoxy-2-naphthyl)ethan-1-one is not genotoxic
Link to relevant study records
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- QSAR prediction is done using the QSAR toolbox version 2.3
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
- Species / strain / cell type:
- other: Chinese Lung cell
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Metabolic activation system:
- S9
- Species / strain:
- other: chinese lung cell
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic. - Executive summary:
The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic.
Reference
The prediction was based on dataset comprised from the following descriptors: "Chromosome aberration"
Estimation method: Taking highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(C)(=O)c1cc2c(cc(OC)cc2)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: C(C)(=O)c1cc2c(cc(OC)cc2)cc1
Threshold=80%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.46
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 3.28
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Additional information from genetic toxicity in vitro:
Genetic toxicity
Based on studies of target substance CAS NO 3900-45-6 and read across reviewed for genetic toxicity from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach.
The summary of the results are presented below
Sr. No |
End point |
Effect |
Species
|
Remarks |
1 |
chromosome aberration |
negative without metabolic activation
|
chinese hamster lung cells
|
Predicted data of target chemical |
2 |
In vitro Genetic toxicity |
negative with metabolic activation
|
S. typhimurium TA 100 |
Predicted data of target chemical |
3 |
In vitro Genetic toxicity
|
negative without metabolic activation |
S. typhimurium TA 100
|
Predicted data of target chemical |
4 |
In vitro Genetic toxicity |
negative with and without metabolic activation |
S. typhimurium TA 1535, TA 1537, TA 98, TA1538 and TA 100 |
Data is from publication for CAS NO 93-08-3 |
5 |
In vitro Genetic toxicity |
negative with and without metabolic activation |
S. typhimurium TA 97, 8 and TA 102 |
Data is from publication for CAS NO 93-08-3 |
6 |
In vitro Genetic toxicity |
negative with and without metabolic activation |
S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 |
Data is from publication for CAS NO 93-04-9 |
Based on the results summarized in above table for the target chemical CAS NO 3900-45-6 and read across, it can be concluded that the substance is non-genotoxic.Thus according to CLP criteria 1-(6-methoxy-2-naphthyl) ethan-1-one is considered to be non-genetic toxic substance.
Justification for selection of genetic toxicity endpoint
The estimated genotoxicity of 1-(6-methoxy-2-naphthyl)ethan-1-one for chinese hamster lung cell of chromosome aberration test using QSAR toolbox version 2.3 is found to be negative. Based on this value and and criteria of classifiction mentioned in new CLP regulation it can be concluded that 1-(6-methoxy-2-naphthyl)ethan-1-one is not genetically toxic.
Justification for classification or non-classification
The subsatnce 1-(6-methoxy-2-naphthyl)ethan-1-one is not genotoxic as per CLP criteria
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