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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The estimated lethal dose concentration of 1-(6-methoxy-2-naphthyl)ethan-1-one for Lepomis macrochirus for 96 hours using QSAR toolbox version 2.3 is 15.18 mg/l. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish

Key value for chemical safety assessment

LC50 for freshwater fish:
15.18 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 39004506 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

15.18299 mg/l

mortality

96 hrs

Lepomis macrochirus

Predicted data for target chemical

2

LC50

42.9921 mg/l

mortality

96 hrs

Oncorhynchus mykiss

Predicted data for target chemical

3

LC50

5.21 mg/l

mortality

96 hrs

Pimephales promelas

Data from DEPAof CAS NO 93-08-3

4

LC50

15.2 mg/l

mortality

48 hrs

Pimephales promelas

Data from study report for CAS NO 119-61-9

5

EC50

14.9 mg/l

mortality

24 hrs

Pimephales promelas

Data from study report for CAS NO 119-61-9

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 5.21 to42.9921mg/l in 96 hrs and 48 hrs and the EC50 value was found to be 14.9 mg/l in 24 hrs on the basis of mortality effect . But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance,, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish (Lepomis macrochirus,Oncorhynchus mykiss and Pimephales promelas)